Does creatine improve cognition?

Based on the clinical research and animal studies, creatine (Cr) supplementation has been demonstrated to improve cognitive function in numerous domains (e.g., short-term memory, spatial memory). Although Cr supplementation seems to be a promising approach for improving some cognitive domains, it is very unknown as to how Cr boost cognitive processing in the brain. We all know that Cr is an energy buffer to react with excessive ATP for energy storage and contributes to form ATP formation when energy demand increases, this area of research still remains to be confirmed. Other possibilities could be that Cr supplementation improves cognitive function through activating certain molecular pathways, resulting in increased synaptogenesis in the brain. For a more thorough understanding of Cr and cognitive function, there are more needed to be done.